Вплив карнітину хлориду на вміст окиснено модифікованих білків та стан антиоксидної системи у щурів різного віку з токсичним ураженням тетрахлорметаном

Abstract

On the model of а toxic defeat of liver bу а tetrachlormethane at male rats of different age periods 3 monthly, (young, preadolescent, weight 70-100 g); 8-10 monthly (puberal, weight 180-220 g); 18-24 monthly ( old, weight 300 g and more) is investigated an intensity of oxidizing updating of proteins of а blood plasma and the activity of enzymes of the 1-st link of antioxidation protection. It is fixed, that under the influence of а tetrachlormethane is most intensive to an oxidizing the pro­tein of the 3 monthly animals, а little bit smaller - old give in, and the oxidizing updating at the adult animals is expressed least. The activity of antioxidation enzymes - superoxidedismutase, glutathioneperoxidase and catalase has an inversely pro­portional character with а degree of the oxidation of proteins. The carnitine chloridum raises activity of antioxidation en­zymes and reduces concentration of oxidatived modificationed proteins. The most expressed effect of work of drugs was observed at adult animals. The deduction about interdependence of а degree of oxidated updating of protein from the activity of antioxidation enzymes and the effectivity of application of carnitine chloridum for normalization of these exponents was made.