Метаболіти вітаміну D у хворих із хронічними вірусними гепатитами і цирозами печінки

Abstract

In 72 patients with chronic liver disorders (37 patients with chronic viral hepatitis and 35 patients with liver ciттhosis) serum contents of basic vitamin D metabolites - 25-hydroxyvitamin D and 1,25-dihydroxycholecalciferal were studied. It was established, that in patients with chronic liver diseases the concentration of these metabolites is significantly lower, and in patients with cirrhosis а considerable decrease of vitamin D metabolites is observed. The concentration of 25-hydroxyvitaпtin D and 1,25-dihydroxycholecalciferal didn't depend on the etiology of chronic hepatitis (there were no significant differences between groups of patients with viral hepatitis В and viral hepatitis С). Among patients with liver cirrhosis, the lowest levels of 25-hydroxyvitamin D and 1,25-dihydroxycholecalciferal were revealed in patients with alcoholic liver cirrhosis and under the decompensation process (Child-Pugh С). The discovered changes of vitamin D metabolites concentration indicate their involvement in the structural and functional bone disorder, particularly, in the development of osteoporosis.