CHANGES OF STRUCTURAL COMPONENTS AND BLOOD VESSELS IN LYMPH NODES AT EXPERIMENTAL OBESITY

Abstract

Obesity is a chronic heterogeneous disease. Has a tendency to recurrent leakage. The purpose of the work was to study changes of structural components and blood vessels of rat mesenteric lymph nodes through different terms of abolition of a high-calorie diet with the prior induction of experimental obesity. Materials and methods. We carried out the study on 66 white rats of reproductive age (5.0-7.0 months) weighing 220-240 g. Microanatomy of the mesenteric lymph nodes structural components in white rats under conditions of physiological norm was studied on 10 intact animals. Experimental animals were divided into 4 groups. With the aid of biochemical blood analysis, it has been investigated determine the glucose, ALT, AST, cholesterol and triglycerides. Results. The level of glucose in the blood of white male rats gradually increases within six weeks after the abolition of a high-calorie diet, but eight weeks after the abolition of a high-calorie diet returns to the level of intact animals. The level of glucose in the blood of white female rats fluctuates throughout the experiment and eight weeks after the abolition of a high-calorie diet by 13% exceeds the rate of intact animals. As a result of our study, we found that two weeks after the abolition of a high-calorie diet in both male and female rats, the number of secondary lymphoid nodules in the cortical substance of the lymph nodes of white rats increases, the hematological centers of which are enlarged, enlightened, arteries and veins are deformed, extended, full-blooded. Six weeks after the abolition of a high-calorie diet, the amount of adipose tissue in the thickness of the capsule and around the organ does not decrease, medullar and cortical lymph sinus remain enlarged and deformed. Conclusions. With the increase in the duration of abolition of a high calorie diet in both male and female rats, the number of secondary lymphoid nodules in the parenchyma of the mesenteric lymph nodes decreases somewhat, around the luminous center there is no clear mantle, medullar, cortical, and marginal lymph sinus are slightly less extensive.