Changes in the structural components of the spleen in experimental obesity and its correction

Abstract

The paper presents and analyzes data from an experimental study conducted on white rats of reproductive age. The aim of the study was to study the morphometric and histological changes of the rat spleen parenchyma in experimental obesity and its correction with melatonin. Eight weeks later, a significant decrease in the relative area of white pulp in the spleen parenchyma of white rats of males and females was observed, and an increase in the relative area of red pulp was observed. After two weeks of HCD, after which six weeks of HCD + melatonin the relative area of white and red pulp almost corresponds to the indicators of intact animals.