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DC Field | Value | Language |
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dc.contributor.author | Девіняк, Олег Теодозійович | - |
dc.contributor.author | Зіменковський, Борис Семенович | - |
dc.contributor.author | Лесик, Роман Богданович | - |
dc.date.accessioned | 2014-12-03T16:00:47Z | - |
dc.date.available | 2014-12-03T16:00:47Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | Devinyak O. Biologically active 4-thiazolidinones: a review of QSAR studies and QSAR modeling of antitumor activity / O. Devinyak, B. Zimenkovsky, R. Lesyk // Current Topics in Medicinal Chemistry – 2012. – Vol. 12(24). – P. 2763-2784. | uk |
dc.identifier.other | DOI: 10.2174/1568026611212240006 | - |
dc.identifier.uri | https://dspace.uzhnu.edu.ua/jspui/handle/lib/265 | - |
dc.description.abstract | 4-Thiazolidinone is a promising scaffold for the search of new potential antibacterial, antiviral, antidiabetic and anticancer agents etc. SAR nalysis of the most potent compounds and different activities evaluation provide a solid background for de novo design of novel drugs. Current review summarizes recent QSAR studies on the 4-thiazolidinones making the emphasis on both technical and interpretative sides of reported models. Several papers among them are devoted to the anticancer activity of 4-thiazolidinone derivatives and are reporting QSAR models that were obtained via multiple linear regressions (MLR). Additionally, a non-linear approach, namely Gaussian processes, has been applied to identify the relationships between 4-thiazolidinones structure and tumor cell growth inhibition. The interpretation of the reported model highlights the core template for the design of new highly-potent anticancer agents and proposes a hypothesis about key role of Hydrogen at the N-atom three bonds away from thiazolidine in the interaction with biotarget. | uk |
dc.language.iso | en | uk |
dc.publisher | Current Topics in Medicinal Chemistry | uk |
dc.subject | Anticancer activity | uk |
dc.subject | Gaussian processes | uk |
dc.subject | QSAR | uk |
dc.subject | rhodanines | uk |
dc.subject | 4-thiazolidinones | uk |
dc.subject | 2,4-thiazolidinediones | uk |
dc.title | Biologically Active 4-Thiazolidinones: A Review of QSAR Studies and QSAR Modeling of Antitumor Activity | uk |
dc.type | Text | uk |
dc.pubType | Стаття | uk |
Appears in Collections: | Наукові публікації кафедри фармацевтичних дисциплін |
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blank self-archiving.doc | 128 kB | Microsoft Word | View/Open |
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