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DC Field | Value | Language |
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dc.contributor.author | Tóth, Štefan | - |
dc.contributor.author | Olexa, Peter | - |
dc.contributor.author | Hertelyová, Zdenka | - |
dc.contributor.author | Kopolovets, Ivan | - |
dc.contributor.author | Berek, Péter | - |
dc.contributor.author | Filip, Vladimír | - |
dc.contributor.author | Chakravarty, Ryan | - |
dc.contributor.author | Široká, Monika | - |
dc.contributor.author | Pella, Dominik | - |
dc.date.accessioned | 2020-12-16T09:42:13Z | - |
dc.date.available | 2020-12-16T09:42:13Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://dspace.uzhnu.edu.ua/jspui/handle/lib/31702 | - |
dc.description.abstract | The aim of this study was to detect the concentrations of PCSK9 in various subclinical stages of atherosclerosis and to highlight its relationship with inflammation. One hundred and fifty-nine healthy patients were divided into three groups, based on the extent of atherosclerotic changes in the carotid artery: A group without identifiable atherosclerosis, cIMT>75‰ and an asymptomatic plaque group. The PCSK9 was measured by ELISA and hsCRP by the immunoturbidimetric method. Vascular changes were identified by a carotid ultrasound. PCSK9 was elevated, when comparing the healthy group with the cIMT>75‰ group; however, no significant increase was detected between cIMT>75‰ and the asymptomatic plaque group. A positive linear correlation of the PCSK9 concentration and atherosclerotic changes was found; however, after the re-analysis in each group, this correlation persisted only in the group with still normal values. Additionally, a significant linear correlation was found between the PCSK9 concentrations and lipid parameters. However, no significant association was found with hsCRP. PCSK9 was found to be elevated only in cIMT>75‰, but not in the later plaque stage. A linear correlation of PCSK9 values was detected only in the group with still reference values. Based on this fact, we assumed the direct linear role of PCSK9 in initiating atherosclerosis; however, in the later phases, the relationship, which highlights other risk factors such as inflammation, is not linear. | uk |
dc.language.iso | en | uk |
dc.publisher | Open Chemistry | uk |
dc.relation.ispartofseries | 1;18 | - |
dc.subject | PCSK9 | uk |
dc.subject | initiation | uk |
dc.subject | inflammation | uk |
dc.subject | atherosclerosis | uk |
dc.subject | plaque | uk |
dc.title | PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation | uk |
dc.type | Text | uk |
dc.pubType | Стаття | uk |
Appears in Collections: | Наукові публікації НДНЦ молекулярної мікробіології та імунології слизових оболонок |
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File | Description | Size | Format | |
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[23915420 - Open Chemistry] PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation.pdf | 422.82 kB | Adobe PDF | View/Open |
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