Please use this identifier to cite or link to this item:
https://dspace.uzhnu.edu.ua/jspui/handle/lib/3888
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Девіняк, Олег Теодозійович | - |
dc.contributor.author | Гаврилюк, Дмитро Ярославович | - |
dc.contributor.author | Авдєєв, Станіслав Сергійович | - |
dc.contributor.author | Чумак, Віра Василівна | - |
dc.contributor.author | Панчук, Ростислав Русланович | - |
dc.contributor.author | Стойка, Ростислав Степанович | - |
dc.contributor.author | Кавсан, Вадим Мусійович | - |
dc.contributor.author | Лесик, Роман Богданович | - |
dc.date.accessioned | 2015-07-31T16:36:05Z | - |
dc.date.available | 2015-07-31T16:36:05Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Virtual Screening and its Experimental Validation Reveal Novel Compounds with Promising Anticancer Activity Among 4-Thiazolidinone- Pyrazoline- and Isatin-Based Conjugates / OT Devinyak, DYa Havrylyuk, SS Avdieiev, VV Chumak, RR Panchuk, RS Stoika, VM Kavsan, RB Lesyk // Austin Journal of Bioorganic & Organic Chemistry. - 2014. - 1(1). - P. 1-6. | uk |
dc.identifier.uri | https://dspace.uzhnu.edu.ua/jspui/handle/lib/3888 | - |
dc.description.abstract | In silico screening of virtual 4-thiazolidinones library has been carried out with several self-developed QSAR and pharmacophore models of anticancer activity. Such approach has allowed us to choose 14 the most probable anticancer hits - conjugates of 4-thiazolidinone, pyrazoline and isatin, which in turn have been synthesized. Half of these compounds were subjected to anticancer activity evaluation and biological experiments confirmed our predictions, although in a qualitative manner. The most sensitive to tested compounds cancer cell line is Mino (the lowest IC50 reached 0.17 μM), which represents mantle cell lymphoma – a rare but very aggressive tumor. That identifies the further direction of biological studies of the novel anticancer hit compounds. | uk |
dc.language.iso | en | uk |
dc.publisher | Austin Journal of Bioorganic & Organic Chemistry | uk |
dc.relation.ispartofseries | 1(1);P. 1-6. | - |
dc.subject | 4-thiazolidinones | uk |
dc.subject | Anticancer activity | uk |
dc.subject | Pharmacophore | uk |
dc.subject | Virtual screening | uk |
dc.title | Virtual Screening and its Experimental Validation Reveal Novel Compounds with Promising Anticancer Activity Among 4-Thiazolidinone- Pyrazoline- and Isatin-Based Conjugates | uk |
dc.type | Text | uk |
dc.pubType | Стаття | uk |
Appears in Collections: | Наукові публікації кафедри фармацевтичних дисциплін |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
virtual screening-ajboc.pdf | 2.62 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.