Зміна пружноеластичних властивостей артеріальних судин у хворих гіпертонічною хворобою під впливом терапії ірбесартаном

Abstract

The present study is devoted to the investigation of the angiotensin II receptor blocker irbesartan on the state of viscoelastic properties of arterial vessels in patients with essential hypertension. 31 patients with essential hypertension and 26 practically healthy subjects were examined. Dopplerography of the common carotid, brachial and femoral arteries have been carried out. Pulse wave velocity, isobaric distensibility and the stiffness koefficient of the aorta and brachial artery were calculated before and 6 month after the treatment with angiotensin II receptor blocker irbesartan. Significant augmentation of the pulse wave velocity and stiffness koefficient and decreasing of isobaric distensibility of the aorta, shows the alteration of viscoelastic properties of elastic type arteries, were detected. There was nо changes of viscoelastic properties of musular type arteries in patients with essential hypertension. The blocade of the pathologic effects of renin-angiotensin system under the influence of treatment with irbesartan caused the significant reduction of stiffness and the normalisation of the viscoelastic properties of elastic type arteries.