Цитомегаловірусна інфекція та атеросклероз

Abstract

It is known that common risk factors of atherosclerosis can explain only 50% of its etiology. Therefore looking for new risk factors of atherosclerosis is necessary. ln recent years the inflammatory-infectious hypothesis of atherosclerosis has beеn reevaluated. The discovery of heavy infections load in the serum of patients with acute coronary syndromes might suggest а potential immunological mechanism triggered bу bacterial proteins. Chlamydia pneumoniae, Helicobacter pylori and Cytomegalovirus infections are very common among the population and therefore they are suspected as the main infectious pathogen in the coronary disease. We found that 90,8% patients with iscemic heart disease was CMV-seropositive vs. 62,5% in control group. Future studies are expected to elucidate further the pathophysiologic relationship between chronic infection and atherosclerosis and to evaluate the potential of а variety of treatment approaches, including antibiotics.