Colon polyps’ detection frequency in elderly and senile patients on the background of NSAIDs therapy

Abstract

is evidence that NSAIDs prevent the formation of colon polyps. The aim: To conduct a comparative analysis of the frequency of colon polyps detection in patients who regularly receive NSAIDs with patients who take NSAIDs regularly with patients not taking drugs of this group. Materials and methods: We conducted colonoscopy in 138 elderly and senile patients. 78 (56.52%) patients regularly received NSAIDs more than 5 years and 60 (43.48%) patients denied regular intake of anti-inflammatory drugs. The indications for the colonoscopy were a positive test for hidden blood in stool and the age of the patients. Patients were prescribed NSAIDs because of the presence of concomitant pathology of the cardiovascular and musculoskeletal system. Results: As a result of our data analysis, we found that colon polyps were detected in 28 (35.89%) patients who regularly received NSAIDs. In patients who did not take NSAIDs colon polyps were detected in 43 (71.67%) cases. Tubular adenomas occurred most often and accounted for 104 (75,36%) cases of all adenomas, whereas tubulovillous adenomas were found in 12 (8.70%) cases, and villous adenomas – in 9 (6.52%) cases. Tubular adenomas are relatively smaller in size. 73.91% of tubular adenomas were less than 3 cm in size, while only 24.64% of tubulovillous and 15.21% of villous adenomas had dimensions up to 1 cm. Conclusions: In patients receiving NSAIDs, the incidence of polyps is significantly lower (p <0.05) compared with patients who does not receive NSAIDs. NSAIDs intake reduces the risk of colon polyps development.