Зміни інтенсивності колагенолізу у волозі передньої камери ока за проникної травми склери, обтяженої введенням ендотоксину в скловидне тіло: вплив парацетамону, діклофенаку, дексаметазону і простагландинів E1, E2, F2α

Abstract

The influence of prostaglandins Е1, Е2 and F2α, paracetamol, diclofenac and dexamethasone on the dynamics of colla­genolytic activity changes in the anterior chamber aqueous humor of rabbit eyes with а penetrating injury of sclera, compli­cated bу endotoxin injection into vitreous was studied. It's postulated, that acute period of а posttraumatic inflammation is characterized bу essential decrease of collagenolysis intensity іn injured eyes. Prostaglandin Е2 causes additional intense in­hibition of collagenolytic activity. The influnce of PGE1, PGF2α, paracetamol, diclofenac and dexamethasone in acute period of inflammation is charactereized bу considerable increase (exceeding control values) of collagen lysis intensity оn injured eyes.