Features of side effects of sulfamethoxazole / Trimethoprim combined pharmacotherapy

Abstract

The aim of this review article is to analyze clinical cases of side effects of sulfamethoxazole / trimethoprim combination therapy with angiotensin-converting enzyme (ACE) inhibitors, potassiumsparing diuretics, angiotensin receptor blockers, methontharin and phenytoin, and phenytoin. Materials and methods. This information was collected based on an analysis of clinical data from Google and PubMed on the side effects of sulfamethoxazole / trimethoprim combination therapy with ACE inhibitors, potassium-sparing diuretics, phenytoin, warfarin and methotrexate. Results. The article systematizes the peculiarities of the side effects of sulfamethoxazole / trimethoprim combined therapy, presents options for eliminating or reducing the risks of side effects. Conclusions. Due to the side effects of sulfamethoxazole / trimethoprim combination therapy, measures should be taken to minimize the risks associated with potentially hazardous sulfamethoxazole / trimethoprim combinations. To do this, physicians should be aware of both the positive and negative effects of combination therapy with sulfamethoxazole / trimethoprim with other drugs.