SOME OF THE PATHOGENETIC MECHANISMS OF THE PANCREATITIS DEVELOPMENT IN TRANSCARPATHIA

Abstract

The paper presents characteristic features of the chronic pancreatitis development in Transcarpathia and their dependence on the clinical form, coprogram analysis, presence of Helicobacter infection, circulating autoantibodies to glutamate decarboxylase (GADA) and islet cells (ICA). Gastropathy is detected in 52-56% of the patients with chronic pancreatitis, 30% of which were associated with Helicobacter infection. Patients with chronic pseudotumor pancreatitis display more pronounced manifestation of maldigestion accompanied by steatorrhea. All forms of chronic pancreatitis show similar signs of amylorrhea. Occurrence of creatorrhea is more frequent in patients with chronic parenchymal pancreatitis. Patients with chronic pancreatitis reveal high frequency of circulating autoantibodies to GADA antigens showing the highest values in the cases of calculous pancreatitis.