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DC Field | Value | Language |
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dc.contributor.author | Horlenko, Olesya M. | - |
dc.contributor.author | Pikina, Iryna Yu. | - |
dc.contributor.author | Prylypko, Lyubomyra B. | - |
dc.contributor.author | Kossey, Gabriella B. | - |
dc.contributor.author | Derbak, Maria A. | - |
dc.contributor.author | Tomey, Adrian I. | - |
dc.contributor.author | Mashyka, Volodymyr Yu. | - |
dc.contributor.author | Горленко, Олеся Михайлівна | - |
dc.contributor.author | Пікіна, Ірина Юріївна | - |
dc.contributor.author | Прилипко, Любомира Богданівна | - |
dc.contributor.author | Коссей, Габріелла Барнабашівна | - |
dc.contributor.author | Дербак, Марія Антонівна | - |
dc.contributor.author | Томей, Адріан Іванович | - |
dc.contributor.author | Машіка, Володимир Юрійович | - |
dc.date.accessioned | 2024-03-13T04:50:31Z | - |
dc.date.available | 2024-03-13T04:50:31Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Respiratory microbiome and its relationship with inflammatory markers / O. M. Horlenko, I. Yu. Pikina, V. Yu. Mashyka, et al. Wiadomości Lekarskie. 2023. Vol. 76, Issue 11. P. 2413–2419. | uk |
dc.identifier.issn | 0043-5147 | - |
dc.identifier.issn | 2719-342X | - |
dc.identifier.other | DOI: 10.36740/WLek202311112 | - |
dc.identifier.uri | https://dspace.uzhnu.edu.ua/jspui/handle/lib/59912 | - |
dc.description.abstract | The aim: This study aims to investigate and analyze the microbiome of the nasopharyngeal zone in acute respiratory infections (ARI) and their relationship with inflammatory markers. Materials and methods: Examination of 112 children (10-14 years old) with acute respiratory infections (ARI) of the upper respiratory tract was carried out. The control group consisted of 25 healthy children identical in age and examination parameters. Results: When analyzing the microflora of the nasopharynx of patients, 29,0% of strains were gram-positive bacteria and 71,0% were gram-negative bacteria (Escherichia coli representing 37,0%). Biochemical examination of the biomaterial revealed the presence of sucrase (n=69), maltase (n=87), lactorepoxidase (n-89) and alcohols - sorbitol (hexahydric alcohol, n=102), mannitol (hexahydric alcohol, n=84), xylitol (pentahydric alcohol, n=86). Regarding the markers of inflammatory response, the following dynamics was noted: increase in the level of IgM (3,91 ± 1,79 g/l, p<0,01) by 2,2 times, elevation of Ig G level by 10 times (145, 91 ± 53,04 g/l, p< 0,01), slightly higher than the reference values IgE level. In addition, increased IL-1, IL-4, IL-6, γ-IFN, TNF-α, Neopterin levels were detected. The level of Thyroid stimulating hormone (TSH) was significantly different compared to the control group (0,62 ± 0,57 vs. 1,98 ± 0,30 mIU/ ml, p< 0,01), but within the reference values. Conclusions: Predominance of Gram-negative bacteria in the nasopharyngeal microflora of patients along with elevated inflammatory markers and lactoperoxydase enzyme predominance was detected in the study. | uk |
dc.language.iso | en | uk |
dc.relation.ispartofseries | Wiadomości Lekarskie; | - |
dc.subject | acute respiratory infections | uk |
dc.subject | nasopharyngeal microflora | uk |
dc.subject | inflammatory markers | uk |
dc.subject | correlation | uk |
dc.subject | children | uk |
dc.title | Respiratory microbiome and its relationship with inflammatory markers | uk |
dc.type | Text | uk |
dc.pubType | Стаття | uk |
Appears in Collections: | Наукові публікації кафедри педіатрії з дитячими інфекційними хворобами |
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