Аналіз коморбідних станів у хворих на ішемічну хворобу серця зі стабільною стенокардією напруження

Abstract

Прогресування ішемічної хвороби серця (ІХС) може залежати від наявності супутніх, ще не до кінця вивчених патофізіологічних механізмів, які не коригуються стандартними схемами лікування. Тому актуальним завданням сучасної медицини є рання діагностика супутніх захворювань і вивчення загальних патогенетичних механізмів ІХС із подальшою розробкою комплексного, персоналізованого підходу до лікування та профілактики коморбідної патології.

The progression of coronary heart disease (CHD) may depend on the presence of concomitant, not yet fully understood pathophysiological mechanisms that are not corrected by standard treatment regimens.Therefore, the urgent task of modern medicine is the early diagnosis of concomitant diseases and the study of common pathogenetic mechanisms of CHD with the further development of a complex, personalized approach to the treatment and prevention of comorbid pathology. The aim of the study was to conduct an analysis of comorbid conditions in patients with coronary heart disease with stable angina pectoris and establish the role of nonalcoholic fatty liver disease in their structure. Materials and methods of the research. Under observation were 1070 patients who were treated at at the Municipal Non-Proϐit Enterprise «Central City Clinical Hospital» in the cardiology department with intensive care units (ICU) with a documented diagnosis of CHD with stable angina pectoris. The studies were conducted with the informed consent of the patients, and their methodology corresponded to the Declaration of Helsinki of 1975 and its revision of 1983 and was approved by the local bioethics commission of UzhNU (Protocol No. 2/20 dated 04.11.2022). Results and discussion. In 276 patients with CHD with stable angina pectoris II FC, diseases of the hepatobiliary system were detected. Among the comorbid lesions of the hepatobiliary system, the following pathologies steatosis, and steatohepatitis. When performing a variance analysis of the examined groups in relation to age and CHD with stable angina pectoris II, statistically signiϐicant indicators were found in patients with diffuse liver damage (p <0.001). Conclusion. Analysis of comorbid conditions in patients with CHD with stable angina pectoris showed that diseases of the hepatobiliary system were registered in every fourth examined, among which diffuse liver diseases were found in 52.5% of patients.