Dynamic indicators of the antioxidant system in children with acute respiratory pathology depending on the therapy scheme

Abstract

Aim: To improve the early diagnosis, course, prediction of the development of Acute Respiratory pathology in children, taking into account the state of antioxidant system (AOS). Materials and Methods: The research group included school-age children (10-14 years old) with Acute Respiratory pathologe (n=111) and a control group (n=25).diseases in comparation. Results: The highest positive correlation between ferritin and TNF- α (r=0,41, p=0,001); Cortisol with Glutathione peroxidase (r=0,35, p=0,006) were observed. Ascorbic acid presented positive interactions on the values of Il-6 and Il-2 (r=0,27, 0,26, respectively). The value of vitamin D is represented in positive interactions with γ-IFN (r=0,30), leptin (r=0,38) and Cu (r=0,32). The negative relationship of Zn with Il-6 was transformed for supporting immune barriers and protein metabolism. Conclusions: The level of Glutathione peroxidase increased in 1,6 times, on the other hand, when the basic therapy was prescribed - in 1,1 times (р3<0,01; р4<0,01; р5<0,01), cortisol level had a reliable tendency to decrease in 1,6. The values of Ascorbic acid increased by almost in 2 times in first group andin 1,4 times in the second group ( p3<0,01; p4<0,01; p5<0,01). After the treatment, the level of vitamin D was identified within the physiological range in the first group. There are also positive effects of optimized therapy on the state of Copper (p3<0,01), Zinc (p3<0,01), Iron (p3=0,04) trace elements in comparison with the data of the second group.