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https://dspace.uzhnu.edu.ua/jspui/handle/lib/21267| Title: | Triphenylphosphine–NBromosuccinimide |
| Authors: | Korol, Nataliya Slivka, Mikhailo |
| Issue Date: | 13-Mar-2018 |
| Citation: | (Ph3P) [603‐35‐0] C18H15P (MW 262.30) InChI = 1S/C18H15P/c1‐4‐10‐16(11‐5‐1)19(17‐12‐6‐2‐7‐13‐17)18‐14‐8‐3‐9‐15‐18/h1‐15H InChIKey = RIOQSEWOXXDEQQ‐UHFFFAOYSA‐N (NBS) [128‐08‐5] C4H4BrNO2 (MW 177.99) InChI = 1S/C4H4BrNO2/c5‐6‐3(7)1‐2‐4(6)8/h1‐2H2 InChIKey = PCLIMKBDDGJMGD‐UHFFFAOYSA‐N (NCS) [128‐09‐6] C4H4ClNO2 (MW 133.54) InChI = 1S/C4H4ClNO2/c5‐6‐3(7)1‐2‐4(6)8/h1‐2H2 InChIKey = JRNVZBWKYDBUCA‐UHFFFAOYSA‐N (NIS) [516‐12‐1] C4H4INO2 (MW 224.99) InChI = 1S/C4H4INO2/c5‐6‐3(7)1‐2‐4(6)8/h1‐2H2 InChIKey = LQZMLBORDGWNPD‐UHFFFAOYSA‐N (conversion of primary alcohols to alkyl halides) Physical Data: See Triphenylphosphine, N‐Bromosuccinimide, N‐Chlorosuccinimide, and N‐Iodosuccinimide. Preparative Method: the mixed reagent is prepared in situ as needed by combining triphenylphosphine, the alcohol, and N‐halosuccinimide in a suitable solvent (usually DMF) and heating. Handling, Storage, and Precautions: precautions in handling should be made as described for the individual reagents. This mixed reagent is not appropriate for storage. Recrystallization of the triphenylphosphine and N‐halosuccinimide is necessary to achieve the most efficient halogenation reaction. In addition, the use of anhydrous solvent is important for the success of the reaction. |
| Series/Report no.: | Encyclopedia of Reagents for Organic Synthesis; |
| Type: | Text |
| Publication type: | Стаття |
| URI: | https://dspace.uzhnu.edu.ua/jspui/handle/lib/21267 |
| Appears in Collections: | Наукові публікації кафедри органічної хімії |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| rt366m.pub2.pdf | 242.23 kB | Adobe PDF | View/Open |
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