Аналіз статевих циклів, гістоструктурних та лектиногістохімічних особливостей ендометрія щурів при експериментальному гіпо- та гіпертироїдизмі

Abstract

By means of routine histological and lectin histochemistry methods rat endometrium and sexual cycle was investigated in experimental hypo- and hyperthyroidism. It was demonstrated that experimental hypothyroidism induced inhibition of female rats sexual cycle and was followed by elevation of leukocytes amount, while hyperthyroidism stimulated developing of decidual cells and collagen fibers. All used lectins expressed affinity to endometrial structures. Thyroid pathology was accompanied with certain shift in lectin binding. In hyperthyroidism all used lectins strongly labeled modified collagen fibers, in hypothyroidism- leukocytes. Our data demonstrate histochemical application of newly purified fungal lectins as well as extend the knowledge about influence of thyroid on endometrium glycoconjugates. Key words: sexual cycle, endometrium, hypothyroidism, hyperthyroidism, lectin histochemistry