Потенціометричний сенсор для визначення мелоксикаму

Abstract

A rapid increase in the development and production of sensors during the last three decades signifies a fundamental change in chemical analysis tools. The most numerous group of these chemical sensors is composed of potentiometric sensors that include ion-selective electrodes (ISEs) Active development of ionometry began with the studies of new chemical sensors and their promising use in pharmaceutical analysis. Currently a wide assortment of commercially available ISEs is being enriched with new developments and improvements in the known types of sensors. Interest in the development of ISEs for the determination of non-steroid anti-inflammatory drugs (NSAIDs), particularly meloxicam, derives from the manifest advantages of the potentiometric technique and by the role of various non-steroid anti-inflammatory drugs in modern pharmacy. They simultaneously anaesthetize the pain and stop the inflammatory process in the human organism; thus they are widely used in the treatment of rheumatoid arthritis and osteoarthrosis. The meloxicam are favorable for the formation of the compounds of the ion associate (IA) type with the basic dyes (BD), particularly with Rhodamine 6G. Such compounds, according to fragmentary data from the literature, can be efficient analytical forms for the potentiometric determination of some NSAIDs. These were the grounds for the assumption that ion associates of meloxicam with a cation dye Rhodamine 6G may be suitable electrode-active substances (EAS) for the development of new sensors for meloxicam. One can see that the possibilities of the potentiometric analysis technique using ion associates of basic dyes as electrode-active substances lack practical implications. The operating рН range of the meloxicam sensor is 5 – 8. The linearity ranges of meloxicam sensor function are (1.0-8.0)×10-5–1×10-2 mol/l, the sensor slope are 26 – 60 mV/decade. The efficiency of the use of sensor for meloxicam determination in pharmaceutical preparations was shown by potentiometric methods.