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https://dspace.uzhnu.edu.ua/jspui/handle/lib/2468| Title: | Лікування лімфатичних мальформацій голови і шиї у дітей |
| Other Titles: | Treatment of the head and neck lymphatic malformations in children |
| Authors: | Кривченя, Д.Ю. Бензар, І.М. |
| Keywords: | лімфатична мальформація, лімфангіома, ОК-432 |
| Issue Date: | 2012 |
| Publisher: | ТОВ «Спектраль» |
| Citation: | Кривченя, Д. Ю. Лікування лімфатичних мальформацій голови і шиї у дітей [Текст] / Д. Ю. Кривченя, І. М. Бензар // Науковий вісник Ужгородського університету / УжНУ. – Ужгород : ТОВ «Спектраль», 2012. – Вип. 2 (44). – С. 68–72. – Бібліогр.: с. 71–72 (16 назв). |
| Series/Report no.: | Медицина; |
| Description: | Lymphatic malphormations (LM) of the head and neck cause cosmetic deformities, swelling and respiratory problems and are difficult to surgically removing. The aim of the study is to determine the efficacy and safetyof the OK-432 (Picibanil) treatment in the management of children with cervicofacialLM.Methods: 18 patients with lymphatic malformations of the head and neck were treated with OK-432 in O.O.Bogomolets National Medical University between January 2011 and March 2012. Treatment consisted of one-four intralesional injection series of OK-432 at two-six months intervals. Response to therapy was evaluating by quantitating change in lesion size and graded as complete (90%–100%), substantial (60%–89%), intermediate (20%–59%), or none (0- 19%).Results. 14 children received OK-432 as first line treatment; three were treated after surgeryand one patient afterprocedure of cryodestruction. 9 (50%) cases were macrocystic LM, 3 (16.7%) – microcystic and 6 (33.3%) were mixed. The best results achieved in patients with macrocystic LM (8 – complete and 1 – substantial), in patients with mixed forms regression was substantial in 4 (66.7%) and intermediate in 2 (33.3%) cases. We didn’t receive any visible result in children with microcystic LM after previous interventions. There was any life threatening complications. Conclusions: OK-432 immunotherapy is aneffective, safe, and simple treatment for themanagement of cervicofacial LM, especiallymacrocystic forms. Previous treatment may impair the effect. Key words: LympaticMalphormations, Lymphangiomas, OK-432 |
| Type: | Text |
| Publication type: | Стаття |
| URI: | https://dspace.uzhnu.edu.ua/jspui/handle/lib/2468 |
| Appears in Collections: | Науковий вісник УжНУ Серія: Медицина. Випуск 2 (44) - 2012 |
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| File | Description | Size | Format | |
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| ЛІКУВАННЯ ЛІМФАТИЧНИХ МАЛЬФОРМАЦІЙ ГОЛОВИ І ШИЇ У ДІТЕЙ.pdf | 619.78 kB | Adobe PDF | View/Open |
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