Bicyclic 6-6 Systems With One Bridgehead Nitrogen Atom: One Extra Heteroatom 1:0

Abstract

This chapter covers the primary chemical literature on the synthetic methodologies, structural features, reactions and applications of the title bicyclic ring systems and their benzo derivatives published between 2008 and 2019. Earlier literature was discussed in Comprehensive Heterocyclic Chemistry III. The aim of this chapter is to give an overview of the diverse methodologies that have been reported on the chemistry of pyrido[2,1-b][1,3]oxazine, pyrido[1,2-c]-[1,3]oxazine, pyrido[2,1-c][1,4]oxazine, pyrido[1,2-b][1,2]oxazine, pyrido[2,1-b][1,3]thiazine, pyrido[2,1-c][1,4]thiazine, pyrido[1,2-b][1,2]thiazine, pyrido[1,2-c][1,3]thiazine, pyrido[1,2-a]-pyrimidine, pyrido[1,2-c]pyrimidine, pyrido[1,2-a]pyrazine, pyrido[1,2-b]pyridazine, pyrido[2,1-f][2,1]azaborine, pyrido[2,1-b][1,3]selenazine and their benzo analogs. This chapter is divided into sections in accordance with the type of extra heteroatom; synthesis, reactivity, structural features, application, and important compounds are discussed within each section.