Changes in the Structural Organization of Lymph Nodes and Biochemical Indicators of Blood Due to the Action of Sodium Glutamate

Abstract

The objective of the research was to study the histological, morphometric and electron microscopic changes of the parenchyma of the lymph nodes and biochemical parameters of the blood of rats under the action of monosodium glutamate for eight weeks. The paper presents and analyzes data from an experimental study conducted on 40 white rats in females and males of reproductive age. After eight weeks of exposure to monosodium glutamate there is a significant decrease in the relative area of the cortical substance in the parenchyma of the lymph nodes and, accordingly, an increase in the relative area of the medullary substance compared with the intact group of animals. Histologically in the parenchyma of the lymph nodes the lumen of the marginal sinus, cortical and medullary intermediate lymphatic sinuses is expanded, the proportion of reticular connective tissue in it increases, and the proportion of lymphocytes decreases, аll parts of the vascular bed undergo changes. Electron microscopically a large number of lymphocytes with signs of karyolysis and karyorrhexis, intercellular spaces are expanded, contain cellular detritus and osmophilic (fatty) inclusions, perivascular spaces are clarified, with signs of edema. Mesenteric lymph nodes change under the influence of monosodium glutamate for eight weeks. Blood levels of glucose, cholesterol, LDL and HDL increase.