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Title: | Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with Type Two Diabetes: A Double-Edged Sword |
Authors: | Petakh P., Петах Павло Владиславович P. Kamyshna I., Камишна І. Nykyforuk A., Никифорук Андрій Ярославович A. et al. |
Keywords: | type 2 diabetes;metformin; COVID-19; SARS-CoV-2; intestinal microbiota; immunoregulation, type 2 diabetes;metformin; COVID-19; SARS-CoV-2; intestinal microbiota; immunoregulation |
Issue Date: | 2022 |
Publisher: | Viruses |
Citation: | Petakh, P.; Kamyshna, I.; Nykyforuk, A.; Yao, R.; Imbery, J.F.; Oksenych, V.; Korda, M.; Kamyshnyi, A. Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with Type Two Diabetes: A Double-Edged Sword. Viruses 2022, 14, 477. |
Abstract: | Coronavirus disease 2019, or COVID-19, is a major challenge facing scientists worldwide. Alongside the lungs, the system of organs comprising the GI tract is commonly targeted by COVID-19. The dysbiotic modulations in the intestine influence the disease severity, potentially due to the ability of the intestinal microbiota to modulate T lymphocyte functions, i.e., to suppress or activate T cell subpopulations. The interplay between the lungs and intestinal microbiota is named the gut–lung axis. One of the most usual comorbidities in COVID-19 patients is type 2 diabetes, which induces changes in intestinal microbiota, resulting in a pro-inflammatory immune response, and consequently, a more severe course of COVID-19. However, changes in the microbiota in this comorbid pathology remain unclear. Metformin is used as a medication to treat type 2 diabetes. The use of the type 2 diabetes drug metformin is a promising treatment for this comorbidity because, in addition to its hypoglycemic action, it can increase amount of intestinal bacteria that induce regulatory T cell response. This dual activity of metformin can reduce lung damage and improve the course of the COVID-19 disease. |
Type: | Text |
Publication type: | Стаття |
URI: | https://dspace.uzhnu.edu.ua/jspui/handle/lib/44971 |
ISSN: | 1999-4915 |
Appears in Collections: | Наукові публікації кафедри біохімії, фармакології та фізичних методів лікування |
Files in This Item:
File | Description | Size | Format | |
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viruses-14-00477-v4.pdf | 2.19 MB | Adobe PDF | View/Open |
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