The role of prooxidant-antioxidant system in the development of alveolitis after teeth extraction

Abstract

The objective of research was to study the features of prooxidant-antioxidant status in patients with postoperative alveolitis. The study involved 2 groups – the control group (healthy) included 10 people; the main group (32 patients after tooth extraction in which postoperative alveolitis developed). To assess the intensity of lipid peroxidation processes in the oral cavity, the determination of the content of secondary products of lipoperoxidation by reaction with thiabarbituric acid was used. To evaluate the performance of the enzymatic link of the oral fluid actioxidant system (AOS), the enzyme activity of the first (superoxide dismutase (SOD) and second (catalase) lines of antiradical protection was determined. The level of malondialdehyde in patients with alveolitis was 1.9 times higher than in the control group; the level of hydroperoxide lipids also increased 8.1 times higher than the control group (p <0.05). A study of the status of antioxidant protection in patients with postoperative alveolitis revealed a statistically significant decrease in SOD content by 51.0 % compared with the group of healthy individuals. Also, we observed a slight increase in catalase activity in the group of patients with alveolitis by 50.0 %. The level of SH-groups in patients of the main group was 2.34 mmol / l and was by 58.6 % statistically significantly lower compared to the same indicator in the control group. Activation of free radical oxidation of biomolecules and depletion of both non-enzymatic (SH-group) and enzymatic (superoxide dismutase) levels of antioxidant protection are observed in the oral fluid of patients with alveolitis, as well as a compensatory increase in catalase activity.