Клініко-імунологічні показники дітей раннього віку, хворих на бронхіальну астму

Abstract

2 clinical groups of comparison have been created. The first one included 80 children with bronchial asthma. The second one included 50 children with obstructive bronchitis. The significant increase of absolute and relative content of CD3 cells was revealed in patients of the first group (76.57±8.07%, 1.75±0.08 G/1). These indexes were 66.31±3.02% and 1.23±0.06 G/ 1 in the second group. The increase of the general amount of T-lymphocytes in the children of the first clinical group is due mainly to the elevated level of the CD4- cells, their function is associated with the helpers. The significant decrease of the intracellular level of peroxidase and cationic proteins in the blood eosinophils was found in children with bronchial asthma. This difference is especially significant for cationic proteins. The concentration of interleukin-4 in the blood serum of children with bronchial asthma is increased compared with those suffering from obstructive bronchitis of viral etiology.