Вплив екзогенних простагландинів і блокаторів синтезу ейкозаноїдів на процеси ліпопероксидації в оці кролика з подвійною проникною травмою склери

Abstract

The influence of prostag!andins (PG) Е1, Е2, F2a, paracetamol, diclofenak and dexamethasone on Iipid peroxidation intensity and activity of the antiradical enzymes of the еуе anterior chamber aqueous humor in the treatment dynamics was investigated іn experiments оn the rabbits with a.double penetrating injury of the sclera. It was shown, that duration of the lipid peroxidation processes' activation after еуе injury reaches 60 days. It was established, that PGE2 increases the dien conjugations content against the backgraund of superoxide dismutase (SD) and glutatione peroxidase (GP) activities reduction. PGE1,paracetamol, diclofenak and dexamethasone decrease the Jipid peroxidation activity with increase of SD and GP- activity, and PGF2a has а maximum effect of the induction of the antioxidant defense system enzymes activity.