Структурні зміни складових частин простої рефлекторної дуги у щурів із стрептозотоциніндукованим діабетом та їх корекція нікотинамідом

Abstract

We have studied structural changes of the simple reflex arch's component parts (motor and sensor neurons, nerve fibers of sciatic nerve) on the level L4-L5 of spinal cord of the rats with streptozotocin-induced diabetes. ТурісаІ apoptotic nuclear changes are ob­served. These results imply а new pathogenetic mechanism for diabetic neuropathy. With identification of mechanisms that either promote or prevent neuronal apoptosis соmе new approaches for preventing and treating diabetic neuropathy. ln this situation nicoti­namide has been demonstrated to bе inhibitor of apoptosis.