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Title: | Association between serum zinc, copper аnd selenium levels and the degree of liver damage in patients with chronic hepatitis c |
Authors: | Sitkar, A. D. Derbak, M. A. Rostoka, L. M. Hanych, O. T. Ганич, Оксана Тарасівна |
Keywords: | chronic hepatitis C, trace elements, liver fibrosis, zinc, FibroMax |
Issue Date: | 2022 |
Publisher: | ALUNA Publishing House |
Citation: | Association between serum zinc, copper and selenium levels and the degree of liver damage in patients with chronic hepatitis C. / Andrii D. Sitkar, Mariya A. Derbak, Larysa M. Rostoka, Oksana T. Hanych. // Wiad Lek. — 2022. — № 76(10). — P. 2392-2396. |
Abstract: | HCV 1b genotype was detected in all patients. The proportion of patients with a high viral load was 32%, with a low viral load – 68%. In 19% of patients, the level of Zn was below normal, and the levels of Cu and Se were within the reference values. The proportion of patients without fibrosis was 32%, 16% had minimal fibrosis, 40% had moderate fibrosis, 8% had progressive fibrosis, and 3% had severe fibrosis. 68% of patients had active inflammation of various degrees, liver steatosis – 65%, non-alcoholic steatohepatitis – 48%, inflammation caused by alcohol consumption was absent. No statistically significant difference was found in serum trace element levels and viral load (p>0.05). A weak negative correlation between the level of Zn and the degree of fibrosis (ρ=-0.340, p=0.007) and a negligible negative correlation between the level of Zn and inflammation activity (ρ=-0.286, p=0.024) were revealed. Patients with fibrosis grade ≥F2 had lower Zn levels compared to patients with fibrosis ≤F1 (0.607 (0.540, 0.691) mg/l vs. 0.716 (0.593, 0.875) mg/l, p=0.01), and when comparing there was no difference in Cu and Se levels (р>0.05). |
Type: | Text |
Publication type: | Стаття |
URI: | https://dspace.uzhnu.edu.ua/jspui/handle/lib/51770 |
Appears in Collections: | Наукові публікації кафедри факультетської терапії |
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