Immunity changes in patients with acute maxillofacial odontogenic infections during treatment stages: an analysis

Abstract

The aim: Evaluate the expediency of using different methods of treatment for patients with acute purulent-odontogenic inflammatory processes in both the main and control groups. This assessment will be based on various indicators of non-specific immunity. Materials and methods: This study involved the evaluation of the humoral component of nonspecific immunity in 114 patients. We assessed changes in total protein and its fractions, C-reactive protein (CRP), lysozyme, and immunoglobulins (A, M, and G) during three distinct time intervals: 1-3 days, 5-7 days, and 8-14 days after treatment initiation. Statistical analysis was conducted using Statistica 10.0 (StatSoft, Inc., USA) and Microsoft Office Excel 2010. Results: At different postoperative follow-up periods, a significant improvement in humoral nonspecific immunity indicators (p>0.05) was observed when comparing patients treated with and without platelet-rich plasma. This improvement is expected to enhance reparative processes and expedite recovery. Conclusions: The incorporation of platelet-rich plasma, immunocorrective, and adaptogenic therapy into the comprehensive treatment of acute purulent odontogenic inflammatory processes in the maxillofacial region not only leads to pronounced and enduring positive outcomes but also results in substantial improvements, including the potential normalization of key humoral and cellular factors associated with innate immunity