The Use of Personalized Pharmabiotics as an Approach to the Rehabilitation of Post-COVID Patients

Abstract

Successful application of defi ned pro- and/prebiotic preparations for the prevention and treatment of viral respiratory infections is confi rmed by meta-analyses and numerous clinical trials. To date, the protocols for the rehabilitation of pa-tients with post-COVID conditions, an integral part of which is the restoration of the balance of gut microbiota along with nutritional supportу, are widely developed and accepted. Purpose. To investigate the effi cacy of individually prescribed pharmabiotics for targeted correction of the nasal and gut microbiota of post-COVID-19 patients in combination with aerosol inhalations. Methods. Th e post-COVID-19 patients were referred to recover using the rehabilitation facilities. In addition to the basic treatment complex, the patients were off ered haloaerosol therapy with an additional prescription of individually selected pharmabiotics. Results. Th e use of individually prescribed pharmabiotics in combination with aerosol inhalation enabled therestoration of Lactobacillus spp. balance and reduction in the number of opportunistic microbiota in the gut. Th us, the personalized rehabilitation approach led to signifi cantly improved local immune response in post-COVID-19 patients. Conclusions. Th e data obtained provide supportive evidence of the effi cacy of aerosol inha-lations and personalized pharmabiotics Lactobacillus rhamnosus S25 and L. plantarum A combined application in the directed modulation of the microbiome and targeted correction of local immunity in post-COVID patients. Restoring the balance of the patient’s’ oral and gut microbiota should be an integral part of the post-COVID patient’s rehabilitation.