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Название: POTENTIAL RISKS OF THE SPREAD OF ANTIBIOTIC-RESISTANT MICROORGANISMS AND ANTIBIOTIC-RESISTANCE GENES IN POTABLE WATER – HUMAN ORGANISM CHAIN
Авторы: Savenko, Maryanna
Kryvtsova, Maryna
Sklar, Ivan
Fogel, Inessa
Ключевые слова: antibiotic resistance genes, oral cavity, potable water, water sources
Дата публикации: апр-2022
Библиографическое описание: Wiadomości Lekarskie, VOLUME LXXV, ISSUE 4 PART 2, APRIL 2022
Краткий осмотр (реферат): ABSTRACT The aim: Determination ofcirculation interrelationsbetween antibiotic-resistantmicroorganismsofEnterobacteriaceaefamilyandtheir resistancegenesin clinicalstrainsand potable water samples taken in Uzhhorodand Uzhhoroddistrict. Materials andmethods: We carried out generic identification of the microorganisms isolated from clinical samples of the oral cavity of 64 patients suffering from periodontal inflammatory diseases, and potable water samples taken from sources of public centralized and decentralized water supply; the isolated microorganisms were tested for antibiotic sensitivity by the Kirby-Bauer disc diffusion method according to EUCAST. With the help of molecular-genetic methods, the total DNA of potable water was isolated and tested for the presence of the following genetic resistance determinants: carbapenems blaNDM; blaOXA48-like; tetracyclines blaTet-M; cephalosporins blaCTX-M. Results: In the microbiota of the clinical material and potable water samples, the same spectrum of microorganisms belonging to Enterobacteriaceae family dominated; the isolated bacteria showed a high resistance level to beta-lactam antibiotics and to natural antibiotic preparations. The highest level of resistance was established for microorganisms isolated from well water samples, where genetic resistance determinants to blaCTX-M cephalosporins and blaTet tetracyclins were also revealed. Conclusions:The obtained results proved high probability of the spread of antibiotic-resistant microorganisms and their genetic resistance determinants via potable water.
Тип: Text
Тип публикации: Стаття
URI (Унифицированный идентификатор ресурса): https://dspace.uzhnu.edu.ua/jspui/handle/lib/66412
Располагается в коллекциях:Навчально-методичні видання кафедри генетики, фізіології рослин та мікробіології

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