Violation of vitamin and mineral homeostasis in children with recurrent respiratory diseases

Abstract

Aim: To examine and analyze the state of vitamin and mineral homeostasis in children with recurrent respiratory diseases. Materials and Methods: To achieve the goal, 62 children of primary school age with a diagnosis of Recurrent Respiratory diseases were examined in comparison with data of healthy children of the control group (n=26). The study included a clinical examination of children, determination of serum vitamin and mineral levels. Results: A dinamic decreasing in the level of vitamins beyond the reference range was found: vitamin D (in 1.4 times ) vitamin C ( in 1.4 times lower than the data of the control group, and Cyanocobalamin (in 1.9 times) in relation to the data of the control group. Calcium levels were below the limit of reference values, both total (2.14 ± 0.04 mmol/l vs. 2.53 ± 0.07 mmol/l, p<0.01) and ionized (1.15 ± 0.01 mmol/l compared 1.26 ± 0.05 mmol/l, p<0.01). At the lower limit of the reference, there were significant differences in the levels of Zinc (p<0.01, 1.6 times), Copper ( p<0.01, 1.4 times) and unreliable - Magnesium (p<0.12), sodium (p<0.62 ). Conclusions: Positive correlations were observed with vitamins - Cyanocobalamin (r=0.40, p<0.01), vitamin C (r=0.43, p<0.01), Ferritin (r=0.35, p<0.01), Magnesium (r=0.27, p<0.003). Negative correlations of vitamins, in particular, Folic acid (r=-0.50, p<0.01), vitamin A (r=-0.40, p<0.01) and Phosphorus minerals (r=-0.75 , p<0.01), Sodium (r=-0.51, p<0.01), Potassium (r=-0.24, p=0.008), Chlorine (r=-0.38, p<0 ,01).