The burdened medical history of the mothers-in-partum – risks for the newborn

Abstract

Aim: To improve early diagnosis in the mothers-in-partum, with a burdened of medical case history, taking into account the pathological pattern «mothernewborn» analysis Materials and Methods: Two groups of mothers-in-partum (n=109) with burdened anamnesis were analyzed, in comparison with mothers of children with control group date(n=31). Results: As for the course of pregnancy, there was a predominance of values of chronic Fetoplacental insuffieciency data (33,91±2,16 vs. 12,92±2,36%, p<0,001), Preeclampsia (38,54±1,67 vs. 22,67±2,48 %, p<0,001) in comparation with control group date. Regarding the course of labour, deliveries by Cesarean section were the most frequent among mothers in the first group in comparison with the data of the control group (55,03±3,28 vs. 45,21±2,48%, p<0,01) along with early discharge of amniotic fluid (44,95±1,39 vs. 38,70±1,46%, p<0,01). Suppression of IL-10 level, is observed at high levels of Anti- Toxoplasma-IgG, as evidenced by the negative correlation between them (r=-0,27, p=0,004). However, Anti-HSV 1/2-IgG does not have a negative effect on the level of Neopterin in infants. The relationship between Anti-CMV-IgG and IL-1 (r=0,75, p<0,001) indicates the stimulation of the inflammatory process in premature infants and inhibition of IL-10 synthesis (r=-0,29, p=0,002 ). Conclusions: A negative correlation between IL-10 level in infants and levels of Anti-Toxoplasma-IgG in mothers, similar relationship was detected regarding Anti-HSV 1/2-IgG on level of TNF-α. Anti-CMV-IgG and IL-1 correlation analysis detected the stimulation of inflammatory process in premature infants and inhibition of IL-10 synthesis.