Вивчення можливостей лікування інфекції Helicobacter pylory і контролю за ерадикацією у дітей і підлітків

Abstract

The great attention is devoted to elaboration of new and more effective schemes of eradication Helicobacter pylori (Нр) of connection with the growth of resistention Нр to antibiotics, which are used for eradication. The question of selection the optimal methods of determination Hp-infection, which could bе used both for determination Нр and for the remote control of the efficiency of the eradication. We conducted eradication Нр in 3 groups Hp-infected children and teenagers with chronic gastritis and duodenal ulcer. In the first group wos patients, who got eradication for the first time. Their scheme of eradication (N1) included: amoxicilline, ·omeprasozole and furazolidone during 7 days. The two groups which followed got Hp-eradication second time: one of them got (N2) with amoxicilline, omeprasozole, clarythromycine and the second group got quadrutherapy (NЗ), which included amoxicilline, bismut subsalicylate, metronidazole and Н2-blосаtоr for 7 days too. The therapy wos а success in 93.8% patients of the first group (highly effective). The high effect of the repeted eradication wos attained bу quadrutherapy (85.7%) in comparison with triple therapy (61.5%). Тhе efficiency of eradication observed bу invasive tests wos mostly always accompanied bу chanches in Ig G titres.