Dynamics of Indicators of Psychoemotional Condition in Patients with Chronic Pancreatitis and Atherosclerosis on the Background of Intestinal Dysbiosis Correction

Abstract

The article describes and analyzes the psycho-emotional state indicators in patients with chronic alcoholicpancreatitis and atherosclerosis against the complex therapy background with the use of probiotics and mela-tonin. All patients were performed clinical-laboratory studies: lipid profile study (determination of total bloodplasma cholesterol (LC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoproteins (LDL),atherogenicity coefficient (CA)); feces research on dysbiosis. The alcoholic etiology of chronic pancreatitis wasdetermined based on anamnestic data and using the AUDIT screening test. The dynamics of psycho-emotionaldisorders were studied using the HADS questionnaire and the ”Emotional Condition Screening” technique. Theemotional state screening was used to evaluate the subjects’ emotional state to identify critically (subclinical andpathological) abnormalities such as hypomania, somatoform, depressive, anxiety states and the tendency toabuse psychoactive substances. The intestinal dysbiosis degree was evaluated according to the classification ofKuvaeva IB, Ladodo KS. (1991).The improvement in the colon microflora was observed in all patients who received Mucofalk and melatoninadditionally to the complex treatment of chronic pancreatitis and atherosclerosis. Decrease in the subclinicaland clinical manifestations of anxiety and depression according to the HADS questionnaire in these patients(subclinical and clinical manifestations of anxiety from 72.1% to 38.7%; subclinical and clinical manifestationsof depression from 65.9% to 36.3 %) was observed after the treatment. According to the Emotional ConditionScreening technique, there was a decrease in the level of pre-clinical and clinical emotional state disorders(hypomania and somatoform disorders; depressive and anxiety states; tendency to abuse psychoactive sub-stances). At the same time, there was an increase in the frequency of emotional state critical indicators on thebackground of a decrease in the emotional disorders’ frequency in general, which we also regarded as somepositive dynamics in such patients.