Production of tumor necrosis factor-α and its soluble type І receptors during cervical papillomavirus infection

Abstract

Spontaneous promoted production of tumor necrosis factor-α by non-fractioned peripheral blood cells occurs as a result of increased severity degree of disease course during cervical papillomavirus infection in women with cervical intraepithelial neoplasm ІІІ and cancer in situ; it is partly due to monocytes activation and higher quantity of CD8+ Т-lymphocytes. Simultaneously, the peripheral cell ability to produce the tumor necrosis factor-α is suppressed following additional stimulation by lipopolysaccharide. This cytokine concentration becomes higher in blood and cervical mucus samples, the disease relapses being accompanied by increased level of the tumor necrosis factor-α soluble receptors type I (p55) in blood sera. The synthesis of the tumor necrosis factor-α becomes normalized following combined treatment including the use of a recombinant interferon-α2 preparation.