The influence of different pathogenically based treatment schemes on the endothelium dysfunction indexes in patients with liver cirrhosis

Abstract

The data about the complex examination and treatment of 64 patients is given. The elliciency of prescribing angiotensin II receptor blocker was proved compared with angiotensin-converting enzyme inhibitors and (3-blockers in combination with prebiotics, probiotics and L-arginine medical preparations. It is found that there are more mini і Tested positive changes in the indexes of dysfunction of endothelium in patients from group 3 (usage of valsartan, n=24), namely: decrease of D-dimer level to 1,68±0,11 ng/ml from 4,01±0,12 ng/ml; endothelin-1 level to 0,52±0,04 fmol/ml from 1,12±0,22 liliol/inl; the level of PgF2a to 97,1±2,2 pg/ml from 217,5 pg/ml; the level of Pg 12 to 79,214,5 pg/ml from 218,4±6,8 pg/ml (p<0,01). This indicates the effect of the proposed treatment scheme on the dysfunction of endothelium indexes dynamics that lies within the basis of the treatment of complication progression at liver cirrhosis.