ДОСЛІДЖЕННЯ ГАЛОГЕНУВАННЯ 3-(1-БУТЕНІЛ)ТІОЕТЕРІВ СИМЕТРИЧНИХ ТРИАЗОЛІВ

Abstract

Chemistry of 1,2,4-triazoles has developed for the last years because of their wide usage in industry and medicine. Electrophilic heterocyclization is one of the main method for synthesis of condensed symmetric heterocyclic compounds. In our previous works we has investigated the electrophilic heterocyclization of allyl-, metallyl-, cynnamyl- and propargyl thioethers of 1,2,4- triazoles and some of them were found as biologically active with antibacterial and fungal action. In this work we have investigated the halogenation of 3-(1-butenyl)thioethers of 1,2,4-triazoles was investigated. DFT calculations of halogenation has provided the formation of thiazynium ring. The annulation of six-member rind and formation of triazolothiazynium salts were proved by NMR spectra.