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Title: | Comparison of the effects of tofacitinib and adalimumab on transclonoscopic pH and calprotectin levels in patients with ulcerative colitis |
Authors: | Varvarynets, Antonina Vasylivna Варваринець, Антоніна Василівна Chubirko, Ksenija Ivanivna Чубірко, Ксенія Іванівна Chopey, Ivan Vasylovych Чопей, Іван Васильович Hnepa, Yana Yuriivna Гнепа, Яна Юріївна Kurakh, Artur Vasylovych Курах, Артур Васильович |
Keywords: | ulcerative colitis, calprotectin, pH-metry |
Issue Date: | Mar-2020 |
Publisher: | Wydawnictwo Aluna ul. Z.M. Przesmyckiego 29, 05-510 Konstancin-Jeziorna Prosimy o dokonywanie wpłat na numer rachunku Wydawnictwa: Credit Agricole Bank Polska S. A.: 82 1940 1076 3010 7407 0000 0000 |
Citation: | Comparison of the effects of tofacitinib and adalimumab on transclonoscopic pH and calprotectin levels in patients with ulcerative colitis. / Antonina V. Varvarynets, Ksenia I. Chubirko, Ivan V. Chopey, Yana Y. Hnepa, Artur V. Kurakh // Wiadomosci Lekarskie. — 2020. — Tom LXXIII. – №3. — P .441—443 |
Series/Report no.: | Wiadomości Lekarskie;2020 tom LXXIII;nr 3 |
Abstract: | ABSTRACT The aim: To investigate the transcolonoscopic pH-metry and calprotectin in patients with ulcerative colitis. Materials and methods: the research included 110 patients both male and female between the ages of 18 to 75 years old, who were treated for UC of medium and severe activity, in active phase. All patients were divided into 3 groups. The first group received standard therapy (ST; n=50), the second group received adalimumab (ADA; n=32), and the third group was treated with tofacitinib (TOF; n=28). The control group consisted of healthy individuals between the ages of 18 and 65 years old. Results: UC patients had lower pH levels in all sections of the large intestine, compared to the control group (р<0,05). Calprotectin level is a better predictor of the course of the disease. Conclusions:Tofacitinib, compared to adalimumab and budesonide, has better influence on clinical, endoscopic and laboratory parameters of UC. KEY WORDS: ulcerative colitis, calprotectin, pH-metry |
Type: | Text |
Publication type: | Стаття |
URI: | https://dspace.uzhnu.edu.ua/jspui/handle/lib/32550 |
Appears in Collections: | Наукові публікації кафедри терапії та сімейної медицини |
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File | Description | Size | Format | |
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Comparison of the effects of tofacitinib and adalimumab.pdf | 2.05 MB | Adobe PDF | View/Open |
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