Comparison of the effects of tofacitinib and adalimumab on transclonoscopic pH and calprotectin levels in patients with ulcerative colitis

Abstract

ABSTRACT The aim: To investigate the transcolonoscopic pH-metry and calprotectin in patients with ulcerative colitis. Materials and methods: the research included 110 patients both male and female between the ages of 18 to 75 years old, who were treated for UC of medium and severe activity, in active phase. All patients were divided into 3 groups. The first group received standard therapy (ST; n=50), the second group received adalimumab (ADA; n=32), and the third group was treated with tofacitinib (TOF; n=28). The control group consisted of healthy individuals between the ages of 18 and 65 years old. Results: UC patients had lower pH levels in all sections of the large intestine, compared to the control group (р<0,05). Calprotectin level is a better predictor of the course of the disease. Conclusions:Tofacitinib, compared to adalimumab and budesonide, has better influence on clinical, endoscopic and laboratory parameters of UC. KEY WORDS: ulcerative colitis, calprotectin, pH-metry