Алкілування 2-меркапто(оксі)тієно[2,3-d]піримідинів

Abstract

It was suggested the method of synthesis of thieno[2,3-d]pyrimidine’s derivatives by cycliza- tion of 2-thioureido(ureido)-3-carbethoxythiophenes from available 2-amino)-3-carbethoxythiophe- nes. Sodium and potassium salts of thieno[2,3-d]pyrimidine’s derivatives were received. Alkylation of sodium salts of 2-mercapto(oxy)- thieno{2,3-d]pyrimidine’s derivatives in etha- nol or in methanol is chemoselective process, which leads to formation of S(O)-alkylderivatives with high yields.