[1,3]Thiazolo[2′,3′:3,4][1,2,4]triazolo[1,5-a]pyrimidines – A New Heterocyclic System Accessed via Bromocyclization

Abstract

A facile access to novel condensed system of [1,3]thiazolo[2′,3′:3,4][1,2,4]triazolo[1,5-a]pyrimidine is presented. This protocol consists of bromine-assisted direct electrophilic heterocyclization of 3-N-allylamine-5,6-dihydro[1,3]thiazolo[2,3-c][1,2,4]triazole. The bromination took place in acetic acid and gave a good yield of the target product, which was dehydrobrominated by sodium acetate action.