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Title: Respiratory microbiome and its relationship with inflammatory markers
Authors: Horlenko, Olesya M.
Pikina, Iryna Yu.
Prylypko, Lyubomyra B.
Kossey, Gabriella B.
Derbak, Maria A.
Tomey, Adrian I.
Mashyka, Volodymyr Yu.
Горленко, Олеся Михайлівна
Пікіна, Ірина Юріївна
Прилипко, Любомира Богданівна
Коссей, Габріелла Барнабашівна
Дербак, Марія Антонівна
Томей, Адріан Іванович
Машіка, Володимир Юрійович
Keywords: acute respiratory infections, nasopharyngeal microflora, inflammatory markers, correlation, children
Issue Date: 2023
Citation: Respiratory microbiome and its relationship with inflammatory markers / O. M. Horlenko, I. Yu. Pikina, V. Yu. Mashyka, et al. Wiadomości Lekarskie. 2023. Vol. 76, Issue 11. P. 2413–2419.
Series/Report no.: Wiadomości Lekarskie;
Abstract: The aim: This study aims to investigate and analyze the microbiome of the nasopharyngeal zone in acute respiratory infections (ARI) and their relationship with inflammatory markers. Materials and methods: Examination of 112 children (10-14 years old) with acute respiratory infections (ARI) of the upper respiratory tract was carried out. The control group consisted of 25 healthy children identical in age and examination parameters. Results: When analyzing the microflora of the nasopharynx of patients, 29,0% of strains were gram-positive bacteria and 71,0% were gram-negative bacteria (Escherichia coli representing 37,0%). Biochemical examination of the biomaterial revealed the presence of sucrase (n=69), maltase (n=87), lactorepoxidase (n-89) and alcohols - sorbitol (hexahydric alcohol, n=102), mannitol (hexahydric alcohol, n=84), xylitol (pentahydric alcohol, n=86). Regarding the markers of inflammatory response, the following dynamics was noted: increase in the level of IgM (3,91 ± 1,79 g/l, p<0,01) by 2,2 times, elevation of Ig G level by 10 times (145, 91 ± 53,04 g/l, p< 0,01), slightly higher than the reference values IgE level. In addition, increased IL-1, IL-4, IL-6, γ-IFN, TNF-α, Neopterin levels were detected. The level of Thyroid stimulating hormone (TSH) was significantly different compared to the control group (0,62 ± 0,57 vs. 1,98 ± 0,30 mIU/ ml, p< 0,01), but within the reference values. Conclusions: Predominance of Gram-negative bacteria in the nasopharyngeal microflora of patients along with elevated inflammatory markers and lactoperoxydase enzyme predominance was detected in the study.
Type: Text
Publication type: Стаття
ISSN: 0043-5147
Appears in Collections:Наукові публікації кафедри педіатрії з дитячими інфекційними хворобами

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