AVDEENKO Anatoly, KONOVALOVA Svetlana, KOMAROVSKA-POROKHNYAVETS Olena, STADNYTSKA Natalyia, LUBENETS Vira. Synthesis and biological activity of quinoid compounds. Chapter 4 in ChemHub – powerful scientific and educational UA-Visegrad tool for the development of green approaches. // Collective monograph under the gen-eral editorship of Vasyl LENDEL/ Electronic edition: Publishing House of UzhNU. – 2024-2025, P.136-156.

Abstract

Quinone oximes and their salts are good bioactive compounds to attain this aim. The alkali metal salts of quinone mono- and dioxime have been synthesized by the reaction of the corresponding quinone oxime with alkali metal hydroxide. Copper {[2-methyl-4-oxo-5-(propan-2-yl)cyclohexa-2,5-dien-1-ylidene]amino}oxidanide shows good activity against Phytophthora infestans. Inhibition of the growth and development of the P. infestans is 80%. N-arylthio-1,4-benzoquinone imines andN-heterylthio- and N-ethylxanthogenato-1,4-benzoquinoneimines were synthesized. Using modern research methods their structures were investigated. A combinatorial library of perspective plant protection means, based on N-arylthio-1,4-benzoquinone imines, was created and their antimicrobial, insecticidal and acaricidal activities were studied. Certain dependencies of the antimicrobial activity of the synthesized compounds on their structure have been established. Using the online ProTox3 platform, the determination of acute toxicity of the synthesized N-arylthio-1,4-benzoquinone imines in silico for rats using four types of substance administration was carried out. New N-heterylthio- and N-ethylxanthogenato-1,4-benzoquinoneimines were synthesized. As a result of the study of the antioxidant activity of these compounds by the absorption method 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), it was found that 2,6-dimethyl-4-{[(ethoxymethanethioyl)sulfanyl]imino}cyclohexa-2,5-dienone exhibits high antioxidant activity.