Синтез похідних 5-діалкіламінометилтіазоло[3,2-b]піримідинів та піримідо[3,2-b]тіазинів

Abstract

2-Alkenilthio-5-dialkylaminomethyl-4-methylpyrimidin-6(1H)-ones were obtained via the condensation of 2-alkenilthiopyrimidin-6(1H)-ones by action of dialkylamines. The rote of bromination of 2-alkenilthio-5-dialkylaminomethyl-4-methylpyrimidin-6(1H)-ones depends on the nature of alkenyl groups and 3-brommethyl-6-dialkylaminomethyl-2,3-dihydro-8H-thiazolo[3,2- b]pyrimidinium and 3-brom-7-dialkylaminomethyl-2,3,4-trihydro-9H-pyrimidino[3,2-b]thiazinium bromides are formed. It is show that the regioselectivity of the reaction is governed by the nature of unsaturated group at sulphuric atom and that the reaction chemoselectivity depends a basicity of nitrogen atoms of pyrimidine heterocycle.