Synthesis of mononuclear heterocycles via electrophilic cyclization

Abstract

The present review covers the scientific literature of the last 15 years on electrophilic cyclization reactions which lead to the formation of a variety of mononuclear heterocyclic compounds: pyrolle, furane, pyrazole, thiazole, oxazole, isoxazole, oxaphosphole, piperidine, pyrane and oxazepane. The majority of the reviewed sources reports studies on the synthesis of five-membered heterocycles. Meanwhile the data on the obtaining of six- and more-membered moieties are lacking. We have discussed the using of different electrophilic agents, catalysts, reaction conditions and synthetic approaches, as well as the possibility of formation of saturated, partially saturated, and aromatic heterocycles.